| Open Message | Enter | Opens the currently selected message. |
| Compose Message | m | Starts composing a new email. |
| Reply to Message | r | Replies to the sender of the selected message. |
| Reply to All | R | Replies to all recipients. |
| Forward Message | f | Forwards the selected email. |
| Delete Message | d | Marks the selected email for deletion. |
| Undelete Message | u | Undoes the deletion mark on the email. |
| Save Message | s | Saves the selected email to another mailbox. |
| Search Messages | / | Searches within the current mailbox. |
| Synchronize Mailbox | $ | Synchronizes the mailbox with the server. |
| Next Unread Message | n | Jumps to the next unread email. |
| Previous Message | k or Up Arrow | Moves to the previous message. |
| Next Message | j or Down Arrow | Moves to the next message. |
| Toggle Read/Unread | C | Toggles read/unread status of an email. |
| Change Folder | c | Opens the folder selection prompt. |
| Close Message View | q | Exits the current view or mailbox. |
| Refresh Mailbox | Ctrl-L | Refreshes the current mailbox view. |
| Tag a Message | t | Tags the selected email. |
| Untag All Messages | T | Removes all tags from messages. |
| Sort Messages | o | Opens sorting options for messages. |
| Quit NeoMutt | Q | Exits NeoMutt entirely. |